Building a biosensor for one-step detection of Bisphenol A

01 June 2015

A new method for detection of Bisphenol A (BPA) was designed based on graphene oxide and anti-BPA aptamer. The graphene oxide can specifically adsorb and quench the fluorescence of fluorescently modified ssDNA probes. The BPA can combine with anti-BPA aptamer and switch its configuration to prevent the aptamer from adsorbing on the surface of graphene oxide.
Under different concentrations of BPA the results show that the intensity of the fluorescence signal was changed. A low limit of detection of 0.05 ng/mL was obtained in the range 0.1–10 ng/mL. The developed method was successfully used to determine BPA in actual water samples (ACS Applied Materials & Interfaces, 23 March 2015).
Click here for an abstract of the article.

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