Thresholds of toxicological concern cosmetics-related substances
This study presents a new, transparent and public TTC database of 552 cosmetics-related chemicals. The 5th percentile POD value for each Cramer Class was determined, from which human exposure threshold values have been derived.
This study also showed that the TTC approach first proposed by the pioneering work of Munro et al. (1996) still holds in a broad sense even after updating multiple details and when many more cosmetics-related chemicals are added. The small impact of a substantially enlarged database and QC effort demonstrates the power and robustness of the probabilistic approach of TTC. An article about this research was published in Food and Chemical Toxicology.
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