The effects of in utero BPA exposure on reproductive capacity
In utero bisphenol A (BPA) exposure affects reproductive function in the first generation of mice; however, not many studies have examined the reproductive effects of BPA exposure on subsequent generations. In this study, pregnant mice were orally dosed with vehicle, BPA or diethylstilbestrol (DES) daily from gestation day 11 until birth.
The results indicate that BPA exposure had significant effects in later generations of mice, like delaying the age at vaginal opening and the age at first estrus. Collectively, these data suggest that BPA exposure affects reproductive function in female mice and that some effects may be transgenerational (Toxicology and Applied Pharmacology, 11 March 2015).
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